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Schematic representation of activated and inhibited Wnt/?-catenin pathway. “WNT ON state?? Upon ligation of Wnts to their receptors composed of frizzled proteins and LRP5/six, the cytoplasmic protein DVL is activated and induces the suppression of GSK3?. Subsequently, stabilized ?-catenin translocates into your nucleus and binds to TCF/LEF transc
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